Endocrine Abstracts

# These authors contributed equallyIntroduction: Adrenocortical carcinoma (ACC) is a rare and aggressive endocrine malignancy with poor prognosis and limited treatment options. In addition, ACC is characterized by endogenous glucocorticoid (GC) excess in 60% of cases which is hypothesized to be one reason, why first clinical trials evaluating the potency of immune checkpoint blockade showed only modest results. Here, we report the identificati...

Background: ED is highly prevalent in HIV-infected men. T leads sexual behavior in men, but preliminary data suggests that ED is poorly related to serum T in HIV--infected men.Aim: To explore the relationship between sexual function and gonadal function in young/middle-aged HIV-infected men.Methodology: Prospective, cross-sectional, observational study on HIV-infected men (age <50 years). Serum TT was assessed by the gold stand...

Aims: Genetic variations mediating matrix metalloproteinase-2 (MMP-2) expression may result in individual differences in susceptibility to particular diseases. Our aim was to investigate the possible association of certain MMP-2 gene variants with type 2 diabetes mellitus (T2DM) in a Tunisian population.Subjects and Methods: A case-control study involving 310 normoglycemic control subjects and 791 T2D patients was performed. A total of four MMP-2 SNPs (-...

Introduction: The predictors of malignancy are important for decision of appropriate management in nodules with atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS). Our aim was to determine the ultrasonographical, clinical and biochemical predictors of malignancy in these patients.Methods: A total of 427 patients with Bethesda Category III (AUS/FLUS) thyroid nodules were included in this retrospective study. We d...

Variants of ADIPOQ have been inconsistently associated with adiponectin level in diverse populations. We explored association of single nucleotide polymorphism (SNP) in the ADIPOQ (+276 G>T, rs1501299) with circulating total adiponectin and insulin resistance (IR) in Ukrainian T2DM cohort.Materials and methods: 544 T2DM patients (M/F: 241/303, age 56.3±0.4 years, diabetes duration 7.8±1.0 years, BMI 31.7&...

Mutation in the genes encoding subunits of the succinate dehydrogenase enzyme complex, SDHB, SDHC and SDHD are associated with an increased risk of developing adrenal or extra-adrenal phaeochromocytoma and cervical paraganglioma. However, the penetrance in large kindreds has seldom been reported and the optimal screening for asymptomatic carriers has not been determined.The index case had a previous history of carotid body tumour and later died with meta...

Background: In March 2022, NICE guidelines advised that real-time continuous glucose monitoring (rtCGM) be offered to all children and young people with type 1 diabetes mellitus (T1DM). Using rtCGM alongside the hybrid closed loop system (HCLS), has transformed management of T1DM in adults and children alike by linking insulin delivery to sensor glucose levels.Aim: To evaluate how the T-Slim pump with control IQ HCLS aff...

We report a rare case of acute myeloid leukaemia (AML) with high risk cytogenetics and associated hypothalamic diabetes insipidus (HDI).A 48-year-old female presented to her GP with a 3-month history of tiredness and lethargy. Full blood count revealed haemoglobin 7.0 g/dl (MCV 103fl), white cell count 12.1×109/l (neutrophils 1.33×109/l), platelets 91×109/l; circulating blast cells were evident on the perip...

The physiological state of pregnancy is characterised by the tolerance of the maternal immune system towards the paternal alloantigens expressed by the foetus. Recently, CD4+CD25+ regulatory T cells (Treg) were described to play an essential role for the generation and maintenance of the tolerance state. Several research groups showed that normal pregnancy in humans and mice is associated with an augmentation in the number of Treg in different organs wher...

Aim: Hashimoto Thyroiditis (HT); is the most common form of hpothyroidism in iodine-sufficient regions. Both genes and and environmental factors are involved in the immunopathological process of HT. Our aim in this study is to determine the prevalence of Thyrothropin Receptor (TSHR), Cytotoxic T Lypmhocyte Antigen-4 (CTLA-4) and Interleukin-1 Receptor Antagonist (IL-1RN) gene polymorphisms associated with HT in Turkish population and the relationship of genotype characteristic...